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Article

Lack of evidence for contribution of intron4a/b polymorphism of endothelial nitric oxide synthase (NOS3) gene to plasma nitric oxide levels.

Acta cardiologica - 1 Apr 2008

Salimi Saeedeh, Firoozrai Mohsen, Nourmohammadi Issa, Shabani Mohammad, Shafiee S Mohammad, Mohebbi Ahmad, Tavilani Heidar

Abstract excerpt

OBJECTIVE: Nitric oxide (NO) is synthesized from L-arginine by endothelium nitric oxide synthase (NOS3). It has been shown that reduced NO synthesis in endothelial cells has been implicated in the development of coronary atherosclerosis. We hypothesized that polymorphisms of NOS3 gene might be associated with increased susceptibility of coronary artery disease (CAD) and plasma NO concentrations. METHODS AND...

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Source

Identifiers

PMID: 18468205
DOI: 10.2143/AC.63.2.2029533

Genes

CAD
NOS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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