Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A comparison among HER2, TP53, PAI-1, angiogenesis, and proliferation activity as prognostic variables in tumours from 408 patients diagnosed with early breast cancer.

Acta oncologica (Stockholm, Sweden) - 1 Jan 2008

Offersen Birgitte Vrou, Alsner Jan, Ege Olsen Karen, Riisbro Rikke, Brünner Nils, Sørensen Flemming Brandt, Sørensen Boe Sandahl, Schlemmer Birgitte Olrik, Overgaard Jens

Abstract excerpt

BACKGROUND: The prognostic potential of HER2, TP53 mutations, PAI-1 protein levels, angiogenesis and proliferation were investigated in tumours from 408 patients with early breast cancer followed >10 years. One hundred and sixty seven patients (41%) died from breast cancer. MATERIALS AND METHODS: Tumour sections were stained for HER2, CD34, and MIB-1. HER2 scores were based on staining intensity, 3+ being...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Cell Growth Processes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Staging

Share to Neovascularization, Pathologic

Share to Plasminogen Activator Inhibitor 1

Share to Receptor, ErbB-2

Share to Tumor Suppressor Protein p53

Share to Ubiquitin-Protein Ligases

Source

Identifiers

PMID: 18465330
DOI: 10.1080/02841860801958295

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A comparison among HER2, TP53, PAI-1, angiogenesis, and proliferation activity as prognostic variables in tumours from 408 patients diagnosed with early breast cancer.PMID 18465330Read ↗

Prognostic molecular markers in early breast cancerSemantic proximity Read ↗

Breast cancer risk stratification based on combined analysis of proliferation and apoptosis.Semantic proximity Read ↗

Circulating Endothelial Cells and Circulating Progenitor Cells in Breast Cancer: Relationship to Endothelial Damage/Dysfunction/ Apoptosis, Clinicopathologic Factors, and the Nottingham Prognostic IndexSemantic proximity Read ↗

Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression.Semantic proximity Read ↗

Angiogenesis markers in breast cancer--potentially useful tools for priority setting of anti-angiogenic agents.Semantic proximity Read ↗

Prognostic factors in node-negative breast cancer: a review of studies with sample size more than 200 and follow-up more than 5 years.Semantic proximity Read ↗

Relationship between p53 gene abnormalities and other tumour characteristics in breast-cancer prognosis.Semantic proximity Read ↗

Signalling networks associated with urokinase‐type plasminogen activator (uPA) and its inhibitor PAI‐1 in breast cancer tissues: new insights from protein microarray analysisSemantic proximity Read ↗

Prognostic role of p27Kip1 and apoptosis in human breast cancer.Semantic proximity Read ↗

The Role of the Plasminogen Activator Inhibitor 1 (PAI1) in Ovarian Cancer: Mechanisms and Therapeutic ImplicationsSemantic proximity Read ↗

Prognostic value of pre-surgical plasma PAI-1 (plasminogen activator inhibitor-1) levels in breast cancer.Semantic proximity Read ↗

Prognostic and predictive indicators in operable breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.