Role of ompR-dependent genes in Salmonella typhimurium virulence: mutants deficient in both ompC and ompF are attenuated in vivo.

doi:10.1128/iai.59.1.449-452.1991

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Article

Role of ompR-dependent genes in Salmonella typhimurium virulence: mutants deficient in both ompC and ompF are attenuated in vivo.

Infection and immunity - 1 Jan 1991

Chatfield S N, Dorman C J, Hayward C, Dougan G

Abstract excerpt

A Salmonella typhimurium strain harboring stable mutations in both ompC and ompF was constructed from the mouse-virulent strain S. typhimurium SL1344. When administered orally to BALB/c mice the strain was attenuated, with the 50% lethal dose (LD50) reduced by approximately 1,000-fold. However, t...

Topics

Animals
Bacterial Outer Membrane Proteins
Genes, Bacterial
Mice
Mice, Inbred BALB C
Mutation
Porins
Salmonella typhimurium
Trans-Activators
Virulence

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