Article
Heterologous protective immunization elicited in mice by Pasteurella multocida fur ompH.
International microbiology : the official journal of the Spanish Society for Microbiology - 1 Mar 2008
Garrido M Elena, Bosch Montserrat, Bigas Anna, Badiola Ignacio, Barbé Jordi, Llagostera Montserrat
Abstract excerpt
Different strategies have been developed to produce vaccines against Pasteurella multocida. The approach described herein involves overexpression on the bacterial cell surface of Fur-regulated IROMPs (iron-regulated outer-membrane proteins). Accordingly, the ability of fur mutants to promote heterologous protection was examined in a Swiss mouse animal model. Twofur mutants derived from P. multocida were isolated,...
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