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Article

The Ams (altered mRNA stability) protein and ribonuclease E are encoded by the same structural gene of Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1991

Babitzke P, Kushner S R

Abstract excerpt

The in vitro and in vivo analysis of the ribonuclease E-deficient (rne-) and the altered mRNA stability protein-deficient (ams-) strains of Escherichia coli has demonstrated that they carry mutations in the same structural gene. Strains encoding either thermolabile RNase E (rne-3071) or Ams protein (ams-1) are defective in both rRNA processing and mRNA turnover. Immediately after a shift to the nonpermissive...

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Identifiers

PMID: 1846032
DOI: 10.1073/pnas.88.1.1
PMCID: PMC50735

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The Ams (altered mRNA stability) protein and ribonuclease E are encoded by the same structural gene of Escherichia coli.PMID 1846032Read ↗

RNase E, an endoribonuclease, has a general role in the chemical decay of Escherichia coli mRNA: evidence that rne and ams are the same genetic locus.Semantic proximity Read ↗

The ams-1 and rne-3071 temperature-sensitive mutations in the ams gene are in close proximity to each other and cause substitutions within a domain that resembles a product of the Escherichia coli mre locus.Semantic proximity Read ↗

The gene specifying RNase E (rne) and a gene affecting mRNA stability (ams) are the same gene.Semantic proximity Read ↗

Genetic studies of cleavage-initiated mRNA decay and processing of ribosomal 9S RNA show that the Escherichia coli ams and rne loci are the same.Semantic proximity Read ↗

Intragenic suppressors of temperature-sensitive rne mutations lead to the dissociation of RNase E activity on mRNA and tRNA substrates in Escherichia coli.Semantic proximity Read ↗

RraA. a protein inhibitor of RNase E activity that globally modulates RNA abundance in E. coli.Semantic proximity Read ↗

Cleavages in the 5' region of the ompA and bla mRNA control stability: studies with an E. coli mutant altering mRNA stability and a novel endoribonuclease.Semantic proximity Read ↗

The proteomic response to mutants of the Escherichia coli RNA degradosome.Semantic proximity Read ↗

Transcriptional regulation of the Escherichia coli gene rraB, encoding a protein inhibitor of RNase E.Semantic proximity Read ↗

Decreased Expression of Stable RNA Can Alleviate the Lethality Associated with RNase E Deficiency in Escherichia coli.Semantic proximity Read ↗

Escherichia coli RNase M is a multiply altered form of RNase I.Semantic proximity Read ↗

RNase G of Escherichia coli exhibits only limited functional overlap with its essential homologue, RNase E.Semantic proximity Read ↗

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