Article
Use of elderly tumor-free subjects as a "supercontrol" for cancer epidemiological studies: pros and cons.
Mechanisms of ageing and development - 1 Jan 2000
Imyanitov Evgeny N
Abstract excerpt
Search for cancer-predisposing single-nucleotide gene polymorphisms is complicated due to weakness of expected associations. We introduced a novel design for molecular epidemiological study, which relies on selection of highly demonstrative cases and controls. It is assumed that patients with clinical features of hereditary predisposition (e.g., cancer bilaterality, or young onset, or presence of family history,...
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