Article
Phenotypic and gene expression diversity of malignant cells in human blast crisis chronic myeloid leukemia.
Differentiation; research in biological diversity - 1 Oct 2008
Simanovsky Masha, Berlinsky Sagi, Sinai Pirchia, Leiba Merav, Nagler Arnon, Galski Hanan
Abstract excerpt
Chronic myeloid leukemia (CML) is considered as a paradigm of neoplasias developing through multistep track. It is believed that in the blast crisis (BC) terminal phase of the disease, blood-circulating blasts represent an expansion of a single CML clone. However, although these blasts grow mostly in suspension under standard culture conditions, a relatively small cell-fraction adheres to the plastic dish. Yet,...
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