Article
A missense mutation in the CHRM2 gene is associated with familial dilated cardiomyopathy.
Circulation research - 6 Jun 2008
Zhang Lin, Hu Aihua, Yuan Haixin, Cui Liang, Miao Guobin, Yang Xinchun, Wang Lefeng, Liu Jinchun, Liu Xiulan, Wang Shuyan, Zhang Zhiyong, Liu Lisheng, Zhao Rongrui, Shen Yan
Abstract excerpt
Circulating autoantibodies against the M2-muscarinic acetylcholine receptor (CHRM2) have been detected in patients with dilated cardiomyopathy (DCM). However, it has yet to be determined whether the pathogenesis of familial DCM may be linked to the genetic variability of the CHRM2 gene. The coding regions of the CHRM2 gene were examined by direct DNA sequencing. Plasma concentrations of autoantibodies against...
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