Article
A comprehensive genetic study of the proteasomal subunit S6 ATPase in German Parkinson's disease patients.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Aug 2008
Wahl Claudia, Kautzmann Sabine, Krebiehl Guido, Strauss Karsten, Woitalla Dirk, Müller Thomas, Bauer Peter, Riess Olaf, Krüger Rejko
Abstract excerpt
Dysfunction of proteasomal protein degradation is involved in neurodegeneration in Parkinson's disease (PD). Recently we identified the regulatory proteasomal subunit S6 ATPase as a novel interactor of synphilin-1, which is a substrate of the ubiquitin-ligase Parkin (PARK2) and an interacting pro...
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