Article
Large-insert genome analysis technology detects structural variation in Pseudomonas aeruginosa clinical strains from cystic fibrosis patients.
Genomics - 1 Jun 2008
Hayden Hillary S, Gillett Will, Saenphimmachak Channakhone, Lim Regina, Zhou Yang, Jacobs Michael A, Chang Jean, Rohmer Laurence, D'Argenio David A, Palmieri Anthony, Levy Ruth, Haugen Eric, Wong Gane K S, Brittnacher Mitch J, Burns Jane L, Miller Samuel I, Olson Maynard V, Kaul Rajinder
Abstract excerpt
Large-insert genome analysis (LIGAN) is a broadly applicable, high-throughput technology designed to characterize genome-scale structural variation. Fosmid paired-end sequences and DNA fingerprints from a query genome are compared to a reference sequence using the Genomic Variation Analysis (GenVal) suite of software tools to pinpoint locations of insertions, deletions, and rearrangements. Fosmids spanning...
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