Article
Sons conceived by assisted reproduction techniques inherit deletions in the azoospermia factor (AZF) region of the Y chromosome and the DAZ gene copy number.
Human reproduction (Oxford, England) - 1 Jul 2008
Mau Kai C, Juul A, McElreavey K, Ottesen A M, Garn I D, Main K M, Loft A, Jørgensen N, Skakkebaek N E, Andersen A Nyboe, Rajpert-De Meyts E
Abstract excerpt
BACKGROUND: Deletions in the azoospermia factor (AZF) region of the Y chromosome are frequent in infertile men. The clinical consequences and the mode of inheritance of these deletions are not yet clear. METHODS: Y chromosome deletion mapping and quantitative PCR analysis of the DAZ-gene copy number, supplemented with haplogroup typing in deleted patients, were performed, in combination with clinical assessments...
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