Article
Identification of multiple post-translational modifications in the porcine brain specific p25alpha.
Journal of neurochemistry - 1 Jul 2008
Kleinnijenhuis Anne J, Hedegaard Claus, Lundvig Ditte, Sundbye Sabrina, Issinger Olaf Georg, Jensen Ole Nørregaard, Jensen Poul Henning
Abstract excerpt
P25alpha is a protein normally expressed in oligodendrocytes and subcellular relocalization of p25alpha occurs in multiple system atrophy, Parkinson's disease and Lewy body dementia along with ectopic expression in neurons. Moreover, it accumulates in Lewy body inclusions with aggregated alpha-synuclein and is a potent stimulator of alpha-synuclein aggregation. P25alpha is a phosphoprotein and post-translational...
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