Tph2 gene variants modulate response control processes in adult ADHD patients and healthy individuals.

doi:10.1038/mp.2008.39

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Article

Tph2 gene variants modulate response control processes in adult ADHD patients and healthy individuals.

Molecular psychiatry - 1 Nov 2009

Baehne C G, Ehlis A-C, Plichta M M, Conzelmann A, Pauli P, Jacob C, Gutknecht L, Lesch K-P, Fallgatter A J

Abstract excerpt

Although therapeutic interventions in attention-deficit/hyperactivity disorder (ADHD) still focus on the dopaminergic system, recent studies indicate a serotonergic dysfunction in this disease as well. In that respect, several variants of the tryptophan hydroxylase gene (TPH2), which codes for the rate-limiting enzyme in the biosynthesis of serotonin (5-HT), have been associated with ADHD. The rs4570625 G-allele...

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Identifiers

PMID: 18427560
DOI: 10.1038/mp.2008.39

Genes

TPH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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