Size fractionation of cell-free DNA in maternal plasma and its application in noninvasive detection of fetal single gene point mutations.

Abstract excerpt

Recent studies have shown that cell-free fetal DNA in maternal plasma can be enriched by means of size fractionation. This technique makes use of the smaller size of fetal DNA fragments compared with maternal DNA fragments isolated simultaneously. On this basis, a highly improved detection of fetal single gene point mutations is permitted. Here, we introduce the use of agarose gel electrophoresis for the size...

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