Article
Size fractionation of cell-free DNA in maternal plasma improves the detection of a paternally inherited beta-thalassemia point mutation by MALDI-TOF mass spectrometry.
Fetal diagnosis and therapy - 1 Jan 2009
Li Ying, Di Naro Edoardo, Vitucci Angeloantonio, Grill Simon, Zhong Xiao Yan, Holzgreve Wolfgang, Hahn Sinuhe
Abstract excerpt
OBJECTIVES: The selective enrichment of cell-free fetal DNA in maternal plasma by size fractionation leads to the improved detection of paternally inherited fetal point mutations when using conventional, real-time PCR, or as has more recently been shown by MALDI-TOF mass spectrometry. We have now examined the use of size fractionation in conjunction with mass spectrometry for the detection of a paternally...
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