Article
MS analysis of single-nucleotide differences in circulating nucleic acids: Application to noninvasive prenatal diagnosis.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2004
Ding Chunming, Chiu Rossa W K, Lau Tze K, Leung Tse N, Chan Li C, Chan Amy Y Y, Charoenkwan Pimlak, Ng Ivy S L, Law Hai-Yang, Ma Edmond S K, Xu Xiangmin, Wanapirak Chanane, Sanguansermsri Torpong, Liao Can, Ai Mary Anne Tan Jin, Chui David H K, Cantor Charles R, Lo Y M Dennis
Abstract excerpt
The analysis of circulating nucleic acids has revealed applications in the noninvasive diagnosis, monitoring, and prognostication of many clinical conditions. Circulating fetal-specific sequences have been detected and constitute a fraction of the total DNA in maternal plasma. The diagnostic reliability of circulating DNA analysis depends on the fractional concentration of the targeted sequence, the analytical...
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