Article
Lack of association between variations of PDE4D and ischemic stroke in the Japanese population.
Stroke - 1 Apr 2009
Matsushita Tomonaga, Kubo Michiaki, Yonemoto Koji, Ninomiya Toshiharu, Ashikawa Kyota, Liang Bailing, Hata Jun, Doi Yasufumi, Kitazono Takanari, Ibayashi Setsuro, Iida Mitsuo, Kiyohara Yutaka, Nakamura Yusuke
Abstract excerpt
BACKGROUND AND PURPOSE: After the first genomewide association study of ischemic stroke identified PDE4D as a susceptible gene, many replication studies have been conducted. However, the validity of the association has remained controversial because of the heterogeneity of both genetic markers and phenotypes. METHODS: We investigated the association between variations of PDE4D and ischemic stroke by 3 methods:...
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