Article
Extent of linkage disequilibrium in Holstein cattle in North America.
Journal of dairy science - 1 May 2008
Sargolzaei M, Schenkel F S, Jansen G B, Schaeffer L R
Abstract excerpt
The success of fine-scale mapping and genomic selection depends mainly on the strength of linkage disequilibrium (LD) between markers and causal mutations. With Lewontin's measure of LD (known as D'), high levels of LD that extend over several million base pairs have been reported in livestock. However, this measure of LD can be strongly biased upward by small samples and by low allele frequencies. The aim of...
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