Article
Onecut transcription factor OC2 is a direct target of T-bet in type-1 T-helper cells.
Genes and immunity - 1 Jun 2008
Furuno K, Ikeda K, Hamano S, Fukuyama K, Sonoda M, Hara T, Sasazuki T, Yamamoto K
Abstract excerpt
T-box transcription factor, T-bet, has a central role in the differentiation of T-helper (Th) progenitor cells to Th1 or Th2 effector cells, partly by regulating the expression of genes such as interferon-gamma (IFN-gamma). However, the direct target genes, especially those mediating the transcriptional network initiated by T-bet, are not yet fully understood. By combining chromatin immunoprecipitation from Th1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.