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Article

Stronger inhibition of gastric acid secretion by lafutidine, a novel H2 receptor antagonist, than by the proton pump inhibitor lansoprazole.

World journal of gastroenterology - 21 Apr 2008

Yamagishi Hatsushi, Koike Tomoyuki, Ohara Shuichi, Horii Toru, Kikuchi Ryousuke, Kobayashi Shigeyuki, Abe Yasuhiko, Iijima Katsunori, Imatani Akira, Suzuki Kaori, Hishinuma Takanori, Goto Junichi, Shimosegawa Tooru

Abstract excerpt

AIM: To compare the antisecretory activity and plasma drug concentrations of a single oral dose of 10 mg lafutidine, a novel H2 receptor antagonist, with those of the proton pump inhibitor lansoprazole (LPZ) 30 mg. METHODS: Ten volunteers without H pylori infection participated in this crossover study comparing lafutidine 10 mg with LPZ 30 mg. Intragastric pH was monitored for 6 h in all participants, and blood...

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Identifiers

PMID: 18416470
DOI: 10.3748/wjg.14.2406
PMCID: PMC2705098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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