Article
Early effects of Lansoprazole orally disintegrating tablets on intragastric pH in CYP2C19 extensive metabolizers.
World journal of gastroenterology - 7 Apr 2008
Yamagishi Hatsushi, Koike Tomoyuki, Ohara Shuichi, Horii Toru, Kikuchi Ryousuke, Kobayashi Shigeyuki, Abe Yasuhiko, Iijima Katsunori, Imatani Akira, Suzuki Kaori, Hishinuma Takanori, Goto Junichi, Shimosegawa Tooru
Abstract excerpt
AIM: To compare rabeprazole (RPZ; 10 mg) with Lansoprazole orally disintegrating tablets (LPZ; 30 mg OD) in terms of antisecretory activity and blood drug concentration after a single dose. METHODS: Eight H pylori -negative cytochrome P450 (CYP) 2C19 extensive metabolizers were assigned to receive a single oral dose of RPZ 10 mg or LPZ 30 mg OD. Twelve hour intragastric pH monitoring was performed on the day of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.