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Article

Pathways to injury in chronic pancreatitis: decoding the role of the high-risk SPINK1 N34S haplotype using meta-analysis.

PloS one - 16 Apr 2008

Aoun Elie, Chang Chung-Chou H, Greer Julia B, Papachristou Georgios I, Barmada M Michael, Whitcomb David C

Abstract excerpt

BACKGROUND: The complex interactions between recurrent trypsin-mediated pancreatic injury, alcohol-associated pancreatic injury and SPINK1 polymorphisms in chronic pancreatitis (CP) are undefined. We hypothesize that CP occurs as a result of multiple pathological mechanisms (pathways) that are initiated by different metabolic or environmental factors (etiologies) and may be influenced differentially by downstream...

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Source

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Identifiers

PMID: 18414673
DOI: 10.1371/journal.pone.0002003
PMCID: PMC2289874

Genes

SPINK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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