Article
Risk of Parkinson disease in carriers of parkin mutations: estimation using the kin-cohort method.
Archives of neurology - 1 Apr 2008
Wang Yuanjia, Clark Lorraine N, Louis Elan D, Mejia-Santana Helen, Harris Juliette, Cote Lucien J, Waters Cheryl, Andrews Howard, Ford Blair, Frucht Steven, Fahn Stanley, Ottman Ruth, Rabinowitz Daniel, Marder Karen
Abstract excerpt
OBJECTIVE: To estimate the risk of Parkinson disease (PD) in individuals with mutations in the Parkin gene. DESIGN: We assessed point mutations and exon deletions and duplications in the Parkin gene in 247 probands with PD (age at onset < or =50 years) and 104 control probands enrolled in the Genetic Epidemiology of Parkinson's Disease (GEPD) study. For each first-degree relative, a consensus diagnosis of PD was...
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