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Article

Prosegment of tripeptidyl peptidase I is a potent, slow-binding inhibitor of its cognate enzyme.

The Journal of biological chemistry - 13 Jun 2008

Golabek Adam A, Dolzhanskaya Natalia, Walus Marius, Wisniewski Krystyna E, Kida Elizabeth

Abstract excerpt

Tripeptidyl peptidase I (TPP I) is the first mammalian representative of a family of pepstatin-insensitive serine-carboxyl proteases, or sedolisins. The enzyme acts in lysosomes, where it sequentially removes tripeptides from the unmodified N terminus of small, unstructured polypeptides. Naturally occurring mutations in TPP I underlie a neurodegenerative disorder of childhood, classic late infantile neuronal...

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Identifiers

PMID: 18411270
DOI: 10.1074/jbc.M800458200
PMCID: PMC2423245

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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