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Article

Increased Neovascularization in Mice Lacking Tissue Inhibitor of Metalloproteinases-3

1 Feb 2011

Abstract excerpt

PURPOSE: Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a matrix-bound inhibitor of matrix metalloproteinases (MMPs). The authors have previously determined a novel function of TIMP-3 to inhibit vascular endothelial growth factor (VEGF)-mediated angiogenesis. Here, the authors examined the in vivo angiogenic phenotype of ocular vessels in mice deficient in TIMP-3. METHODS: VEGF-mediated corneal...

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Identifiers

PMID: 21282576
DOI: 10.1167/iovs.10-5899

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Increased Neovascularization in Mice Lacking Tissue Inhibitor of Metalloproteinases-3PMID 21282576Read ↗

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The Gene Structure of Tissue Inhibitor of Metalloproteinases (TIMP)-3 and Its Inhibitory Activities Define the Distinct TIMP Gene FamilySemantic proximity Read ↗

A novel tissue inhibitor of metalloproteinases-3 mutation reveals a common molecular phenotype in Sorsby's fundus dystrophy.Semantic proximity Read ↗

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Temporal and spatial regulation of gene expression mediated by the promoter for the human tissue inhibitor of metalloproteinases-3 (TIMP-3)-encoding geneSemantic proximity Read ↗

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