Article
HLA-DR and DQ antigens and anticardiolipin antibodies in women with recurrent spontaneous abortions.
American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Dec 1991
Trabace S, Nicotra M, Cappellacci S, Morellini M, Muttinelli C, Sbracia M, Di Prima M A, Masala C
Abstract excerpt
IgG anticardiolipin antibodies (ACL) have been shown to occur in a high proportion of women with repeated unexplained miscarriages. Forty-nine women with unexplained recurrent spontaneous abortions (RSA), previously assayed for the presence of ACL by an enzyme-linked immunoabsorbent assay, were typed for HLA-DR and DQ antigens by the classical microlymphocytotoxicity test. Twenty-five women were positive for ACL...
Topics
- Abortion, Habitual
- Antibodies, Anticardiolipin
- Antiphospholipid Syndrome
- Disease Susceptibility
- Female
- Genes, MHC Class II
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- HLA-DR Antigens
- HLA-DR7 Antigen