Article
MS-275, a novel histone deacetylase inhibitor with selectivity against HDAC1, induces degradation of FLT3 via inhibition of chaperone function of heat shock protein 90 in AML cells.
Leukemia research - 1 Sept 2008
Nishioka Chie, Ikezoe Takayuki, Yang Jing, Takeuchi Seisho, Koeffler H Phillip, Yokoyama Akihito
Abstract excerpt
This study explored the effect of MS-275, a novel histone deacetylase inhibitor (HDACI), against a variety of human leukemia cells with defined genetic alterations. MS-275 profoundly induced growth arrest of acute myelogenous leukemia (AML) MOLM13 and biphenotypic leukemia MV4-11 cells, which possess internal tandem duplication mutation in the fms-like tyrosine kinase 3 (FLT3) gene (FLT3-ITD), with IC50s less...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.