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Article

First Report of <i>cfr</i> -Mediated Resistance to Linezolid in Human Staphylococcal Clinical Isolates Recovered in the United States

8 Apr 2008

Abstract excerpt

Linezolid resistance has dominantly been mediated by mutations in 23S rRNA or ribosomal protein L4 genes. Recently, cfr has demonstrated the ability to produce a phenotype of resistance to not only oxazolidinones, but also other antimicrobial classes (phenicols, lincosamides, pleuromutilins, and streptogramin A). We describe the first detection of cfr-mediated linezolid resistance in Staphylococcus aureus and...

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PMID: 18391032
DOI: 10.1128/aac.00231-08

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