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Article

Binding of DAZAP1 and hnRNPA1/A2 to an exonic splicing silencer in a natural BRCA1 exon 18 mutant.

Molecular and cellular biology - 1 Jun 2008

Goina Elisa, Skoko Natasa, Pagani Franco

Abstract excerpt

A disease-causing G-to-T transversion at position +6 of BRCA1 exon 18 induces exclusion of the exon from the mRNA and, as has been suggested by in silico analysis, disrupts an ASF/SF2-dependent splicing enhancer. We show here using a pulldown assay with an internal standard that wild-type (WT) and mutant T6 sequences displayed similar ASF/SF2 binding efficiencies, which were significantly lower than that of a...

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Share to Alternative Splicing
Share to BRCA1 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterogeneous Nuclear Ribonucleoprotein A1

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Source

Open in PubMed Open full text

Identifiers

PMID: 18391021
DOI: 10.1128/MCB.02253-07
PMCID: PMC2423284

Genes

BRCA1
DAZAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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