Article
Activin in the brain modulates anxiety-related behavior and adult neurogenesis.
PloS one - 2 Apr 2008
Ageta Hiroshi, Murayama Akiko, Migishima Rika, Kida Satoshi, Tsuchida Kunihiro, Yokoyama Minesuke, Inokuchi Kaoru
Abstract excerpt
Activin, a member of the transforming growth factor-beta superfamily, is an endocrine hormone that regulates differentiation and proliferation of a wide variety of cells. In the brain, activin protects neurons from ischemic damage. In this study, we demonstrate that activin modulates anxiety-related behavior by analyzing ACM4 and FSM transgenic mice in which activin and follistatin (which antagonizes the activin...
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