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Article

Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy

31 Mar 2008

Abstract excerpt

Strategies to treat cancer have focused primarily on the killing of tumor cells. Here, we describe a differential stress resistance (DSR) method that focuses instead on protecting the organism but not cancer cells against chemotherapy. Short-term starved S. cerevisiae or cells lacking proto-oncogene homologs were up to 1,000 times better protected against oxidative stress or chemotherapy drugs than cells...

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PMID: 18378900
DOI: 10.1073/pnas.0708100105

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