Article
PTPN22 gene polymorphism in Takayasu's arteritis.
Rheumatology (Oxford, England) - 1 May 2008
Sahin N, Aksu K, Kamali S, Bicakcigil M, Ozbalkan Z, Fresko I, Ozer H, Akar S, Onat A M, Cobankara V, Kiraz S, Oztürk M A, Tunç E, Yücel E, Ates A, Keser G, Inanc M, Direskeneli H, Saruhan-Direskeneli G
Abstract excerpt
OBJECTIVE: Takayasu's arteritis (TA) is a chronic, rare granulomatous panarteritis of unknown aetiology involving mainly the aorta and its major branches. In this study, genetic susceptibility to TA has been investigated by screening the functional single nucleotide polymorphism (SNP) of PTPN22 gene encoding the lymphoid-specific protein tyrosine phosphatase. METHODS: Totally, 181 patients with TA and 177 healthy...
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