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Article

Discovering regulators of the Drosophila cardiac hypoxia response using automated phenotyping technology.

Annals of the New York Academy of Sciences - 1 Mar 2008

Feala Jacob D, Omens Jeffrey H, Paternostro Giovanni, McCulloch Andrew D

Abstract excerpt

Necrosis and apoptosis during acute myocardial infarction result in part from the inability of hypoxic cardiac myocytes to match ATP supply and demand. In contrast, hypoxia-tolerant organisms, such as Drosophila, can rapidly regulate cellular metabolism to survive large oxygen fluctuations. A genetic screen of fly heart function during acute hypoxia can be an unbiased way to discover essential enzymes and novel...

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PMID: 18375589
DOI: 10.1196/annals.1420.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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