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Article

X-ray structures of Aerococcus viridans lactate oxidase and its complex with D-lactate at pH 4.5 show an alpha-hydroxyacid oxidation mechanism.

Journal of molecular biology - 25 Apr 2008

Furuichi Makio, Suzuki Nobuhiro, Dhakshnamoorhty Balasundaresan, Minagawa Hirotaka, Yamagishi Ryosuke, Watanabe Yuta, Goto Yukari, Kaneko Hiroki, Yoshida Yoshihito, Yagi Hirotaka, Waga Iwao, Kumar Penmetcha K R, Mizuno Hiroshi

Abstract excerpt

L-Lactate oxidase (LOX) belongs to a family of flavin mononucleotide (FMN)-dependent alpha-hydroxy acid-oxidizing enzymes. Previously, the crystal structure of LOX (pH 8.0) from Aerococcus viridans was solved, revealing that the active site residues are located around the FMN. Here, we solved the crystal structures of the same enzyme at pH 4.5 and its complex with d-lactate at pH 4.5, in an attempt to analyze the...

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Identifiers

PMID: 18367206
DOI: 10.1016/j.jmb.2008.02.062

Genes

LOX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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