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Article

Correctors promote folding of the CFTR in the endoplasmic reticulum.

The Biochemical journal - 1 Jul 2008

Loo Tip W, Bartlett M Claire, Clarke David M

Abstract excerpt

Cystic fibrosis (CF) is most commonly caused by deletion of a residue (DeltaF508) in the CFTR (cystic fibrosis transmembrane conductance regulator) protein. The misfolded mutant protein is retained in the ER (endoplasmic reticulum) and is not trafficked to the cell surface (misprocessed mutant). Corrector molecules such as corr-2b or corr-4a are small molecules that increase the amount of functional CFTR at the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18361776
DOI: 10.1042/BJ20071690

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Correctors promote folding of the CFTR in the endoplasmic reticulum.PMID 18361776Read ↗

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