Article
The N-terminus of the fragile X mental retardation protein contains a novel domain involved in dimerization and RNA binding.
Biochemistry - 9 Sept 2003
Adinolfi S, Ramos A, Martin S R, Dal Piaz F, Pucci P, Bardoni B, Mandel J L, Pastore A
Abstract excerpt
Fragile X syndrome, the most common cause of inherited mental retardation, is caused by the absence of the fragile X mental retardation protein (FMRP). The emerging picture is that FMRP is involved in repression of translation through a complex network of protein-protein and protein-RNA interactions. Very little structural information is, however, available for FMRP that could help to understand its function. In...
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