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Erythropoietin receptor transcription is neither elevated nor predictive of surface expression in human tumour cells

1 Mar 2008

Abstract excerpt

Erythropoietin receptor (EpoR) has been reported to be overexpressed in tumours and has raised safety concerns regarding the use of erythropoiesis-stimulating agents (ESAs) to treat anaemia in cancer patients. To investigate the potential for EpoR to be overexpressed in tumours, we have evaluated human tumours for amplification of the EPOR locus, levels of EPOR transcripts, and expression of surface EpoR protein....

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PMID: 18349818
DOI: 10.1038/sj.bjc.6604220

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