Article
A structurally abnormal erythropoietin receptor gene in a human erythroleukemia cell line.
Experimental hematology - 1 Mar 1992
Ward J C, Harris K W, Penny L A, Forget B G, Kitamura T, Winkelmann J C
Abstract excerpt
Restriction endonuclease mapping demonstrates a 3' end deletion of one erythropoietin receptor (EpoR) gene in TF-1 cells, a human erythroleukemia cell line that overexpresses the EpoR and proliferates in response to erythropoietin (Epo). EpoR mRNA transcripts are highly abundant and normal in size. These findings raise interesting questions about the possible role of this EpoR gene abnormality in the pathogenesis...
Topics
- Blotting, Northern
- Blotting, Southern
- Chromosome Mapping
- DNA Restriction Enzymes
- Erythropoietin
- Humans
- Leukemia, Erythroblastic, Acute
- Mutation
- Receptors, Cell Surface
- Receptors, Erythropoietin
- Transcription, Genetic