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Article

Heterogeneity in the polarity of Nra regulatory effects on streptococcal pilus gene transcription and virulence.

Infection and immunity - 1 Jun 2008

Luo Feng, Lizano Sergio, Bessen Debra E

Abstract excerpt

Transcription of several key virulence factors of Streptococcus pyogenes is under the control of Mga and Nra/RofA. In an M serotype 49 (M49) strain, Nra is a negative regulator of pilus gene transcription; also, Nra represses mga expression, leading to downregulation of the M protein surface fibril and secreted cysteine protease SpeB. In this report, the role of Nra in the virulence of an M53 classical skin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18347035
DOI: 10.1128/IAI.01567-07
PMCID: PMC2423052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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