Increase in P-glycoprotein accompanied by activation of protein kinase Calpha and NF-kappaB p65 in the livers of rats with streptozotocin-induced diabetes.

doi:10.1016/j.bbadis.2008.02.005

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Increase in P-glycoprotein accompanied by activation of protein kinase Calpha and NF-kappaB p65 in the livers of rats with streptozotocin-induced diabetes.

Biochimica et biophysica acta - 1 May 2008

Kameyama Natsumi, Arisawa Sakiko, Ueyama Jun, Kagota Satomi, Shinozuka Kazumasa, Hattori Ai, Tatsumi Yasuaki, Hayashi Hisao, Takagi Kenji, Wakusawa Shinya

Abstract excerpt

It is known that protein kinase C (PKC) signal transduction is enhanced in a diabetic state, and that PKC activator phorbol esters increase the gene expression of MDR1 in human tumor cells. To clarify the expression of the liver transporters under diabetic conditions and the roles of PKCalpha and the transcription factor NF-kappaB, we investigated the expression levels of Mdr1a, Mdr1b, Mdr2, Mrp2, Bcrp, Bsep,...

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Increase in P-glycoprotein accompanied by activation of protein kinase Calpha and NF-kappaB p65 in the livers of rats with streptozotocin-induced diabetes.

Abstract excerpt

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