Article
Undifferentiated mesenchymal stem cells seeded on a vascular prosthesis contribute to the restoration of a physiologic vascular wall.
Journal of vascular surgery - 1 Jun 2008
Mirza Alain, Hyvelin Jean-Marc, Rochefort Gael Y, Lermusiaux Patrick, Antier Daniel, Awede Bonaventure, Bonnet Pierre, Domenech Jorge, Eder Veronique
Abstract excerpt
BACKGROUND: We evaluated the possibility of restoring a physiologic vascular wall using undifferentiated mesenchymal stem cells (MSCs) seeded on a polyurethane vascular prosthesis. METHODS: Undifferentiated MSCs were seeded on a vascular prosthesis and implanted into Wistar male rats (weight, 350 g) to investigate differentiation into smooth muscle cells and to determine graft endothelialization in vivo. RESULTS:...
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