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Article

Tumor cell killing mechanisms of epidermal growth factor receptor (EGFR) antibodies are not affected by lung cancer-associated EGFR kinase mutations.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2008

Peipp Matthias, Schneider-Merck Tanja, Dechant Michael, Beyer Thomas, Lammerts van Bueren Jeroen J, Bleeker Wim K, Parren Paul W H I, van de Winkel Jan G J, Valerius Thomas

Abstract excerpt

The epidermal growth factor receptor (EGFR) serves as a molecular target for novel cancer therapeutics such as tyrosine kinase inhibitors (TKI) and EGFR Abs. Recently, specific mutations in the EGFR kinase domain of lung cancers were identified, which altered the signaling capacity of the receptor and which correlated with clinical response or resistance to TKI therapy. In the present study, we investigated the...

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Share to Antibodies, Neoplasm
Share to Antibody-Dependent Cell Cytotoxicity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Epidermal Growth Factor

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Share to Gene Expression Regulation, Enzymologic

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Source

Identifiers

PMID: 18322248
DOI: 10.4049/jimmunol.180.6.4338

Genes

EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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