Article
Costimulatory strength influences the differential effects of transforming growth factor beta1 for the generation of CD8+ regulatory T cells.
Molecular immunology - 1 May 2008
Fan Timothy M, Kranz David M, Flavell Richard A, Roy Edward J
Abstract excerpt
Transforming growth factor beta1 (TGFbeta1) is a pleiotropic cytokine, capable of exerting diverse biologic effects. Despite its central role in multiple immune activities, the molecular signals responsible for shaping TGFbeta1's immunologic properties remain poorly elucidated. We report that costimulatory strength acts as a molecular switch, which influences the differential effects of TGFbeta1 on the effector...
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