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Article

Evolution of the hepcidin gene in primates.

BMC genomics - 5 Mar 2008

Segat Ludovica, Pontillo Alessandra, Milanese Michele, Tossi Alessandro, Crovella Sergio

Abstract excerpt

BACKGROUND: Hepcidin/LEAP-1 is an iron regulatory hormone originally identified as an antimicrobial peptide. As part of a systematic analysis of the evolution of host defense peptides in primates, we have sequenced the orthologous gene from 14 species of non-human primates. RESULTS: The sequence of the mature peptide is highly conserved amongst all the analyzed species, being identical to the human one in great...

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Identifiers

PMID: 18321376
DOI: 10.1186/1471-2164-9-120
PMCID: PMC2294130

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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