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Article

Adaptive Evolution of Hepcidin Genes in Antarctic Notothenioid Fishes

29 Feb 2008

Abstract excerpt

Hepcidin is a small bioactive peptide with dual roles as an antimicrobial peptide and as the principal hormonal regulator of iron homeostasis in human and mouse. Hepcidin homologs of very similar structures are found in lower vertebrates, all comprise approximately 20-25 amino acids with 8 highly conserved cysteines forming 4 intramolecular disulfide bonds, giving hepcidin a hairpin structure. Hepcidins are...

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PMID: 18310660
DOI: 10.1093/molbev/msn056

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