Article
A candidate complex approach to study functional mitochondrial DNA changes: sequence variation and quaternary structure modeling of Drosophila simulans cytochrome c oxidase.
Journal of molecular evolution - 1 Mar 2008
Melvin Richard G, Katewa Subhash D, Ballard J William O
Abstract excerpt
A problem with studying evolutionary dynamics of mitochondrial (mt) DNA is that classical population genetic techniques cannot identify selected substitutions because of genetic hitchhiking. We circumvented this problem by employing a candidate complex approach to study sequence variation in cytochrome c oxidase (COX) genes within and among three distinct Drosophila simulans mtDNA haplogroups. First, we...
Topics
- Animals
- DNA, Mitochondrial
- Drosophila
- Electron Transport Complex IV
- Genetic Variation
- Models, Molecular
- Protein Structure, Quaternary