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Article

Prospective study of homocysteine and MTHFR 677TT genotype and risk for venous thrombosis in a general population--results from the HUNT 2 study.

British journal of haematology - 1 May 2008

Naess Inger Anne, Christiansen Sverre C, Romundstad Pål R, Cannegieter Suzanne C, Blom Henk J, Rosendaal Frits R, Hammerstrøm Jens

Abstract excerpt

This case-cohort designed study prospectively investigated whether elevated homocysteine levels measured in blood samples drawn before the event and methylenetetrahydrofolate reductase (MTHFR) gene polymorphism (MTHFR C677T) were associated with subsequent first venous thrombosis (VT) in a genera...

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Source

Identifiers

PMID: 18318759
DOI: 10.1111/j.1365-2141.2008.07073.x

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18318759-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prospective study of homocysteine and MTHFR 677TT genotype and risk for venous thrombosis in a general population--results from the HUNT 2 study.PMID 18318759Read ↗

Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies.Semantic proximity Read ↗

Clinical significance of determining plasma homocysteine: case-control study on arterial and venous thrombotic patients.Semantic proximity Read ↗

No association between the common MTHFR 677C->T polymorphism and venous thrombosis: results from the MEGA study.Semantic proximity Read ↗

Mutations C677T and A1298C of the 5,10-methylenetetrahydrofolate reductase gene and fasting plasma homocysteine levels are not associated with the increased risk of venous thromboembolic disease.Semantic proximity Read ↗

Prospective study of first stroke in relation to plasma homocysteine and MTHFR 677C>T and 1298A>C genotypes and haplotypes - evidence for an association with hemorrhagic stroke.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphism (C677T), hyperhomocysteinemia, and risk of ischemic cardiovascular disease and venous thromboembolism: prospective and case-control studies from the Copenhagen City Heart StudySemantic proximity Read ↗

Hyperhomocysteinemia increases the risk of venous thrombosis independent of the C677T mutation of the methylenetetrahydrofolate reductase gene in selected Brazilian patients.Semantic proximity Read ↗

Association study of methylenetetrahydrofolate reductase C677T mutation with cerebral venous thrombosis in an Iranian population.Semantic proximity Read ↗

THROMBOTIC RISK EVALUATION OF TWO METHYLENETETRAHYDROFOLATE REDUCTASE MUTATIONS C677t AND A1298c IN VENOUS THROMBOEMBOLISM.Semantic proximity Read ↗

MTHFR A1298C and C677T Polymorphisms Are Associated with Increased Risk of Venous Thromboembolism: A Retrospective Chart Review Study.Semantic proximity Read ↗

Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology (LITE).Semantic proximity Read ↗

No interaction between factor V Leiden and hyperhomocysteinemia or MTHFR 677TT genotype in venous thrombosis. Results of a meta-analysis of published studies and a large case-only study.Semantic proximity Read ↗

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