Detecting Lynch syndrome by pathologists.

Abstract excerpt

Lynch syndrome (formerly called hereditary nonpolyposis colorectal cancer) is a hereditary syndrome resulting in a high risk for colorectal cancer at young age. About 2-3% of all colorectal cancers arise in the setting of Lynch syndrome and the tumors are characterized by microsatellite instabillity (MSI)due to a mutation in one of the mismatch repair genes. Of sporadic colorectal cancer about 15 % have MSI too,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Colorectal Neoplasms, Hereditary Nonpolyposis
• Share to Germ-Line Mutation