Article
The GLUT-1 XbaI gene polymorphism is associated with vascular calcifications in nondiabetic uremic patients.
Nephron. Clinical practice - 1 Jan 2008
Rufino Margarita, Hernández Domingo, Barrios Ysamar, Salido Eduardo
Abstract excerpt
BACKGROUND: Glucose transporters mediate the facilitative uptake of glucose into cells, with GLUT-1 being the predominant isoform in vascular smooth muscle cell (VSMC). Clones of human cells overexpressing the GLUT-1 transporter showed a high increase in intracellular glucose concentrations, mimicking the diabetic milieu. It is possible that high intracellular glucose together with uremic factors may play an...
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