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Article

Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma.

FEBS letters - 19 Mar 2008

Morton Simon, Hesson Luke, Peggie Mark, Cohen Philip

Abstract excerpt

TANK-binding kinase 1 (TBK1) was identified as a binding partner for Optineurin (OPTN) in two-hybrid screens, an interaction confirmed by overexpression/immunoprecipitation experiments in HEK293 cells and by coimmunoprecipitation of endogenous OPTN and TBK1 from cell extracts. A TBK1 binding site...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18307994
DOI: 10.1016/j.febslet.2008.02.047

Genes

TBK1
OPTN
TANK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18307994-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma.PMID 18307994Read ↗

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ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase functionSemantic proximity Read ↗

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